·  Abstracts on T Wave Alternans

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·  ·  TITLE

Published Papers

Selected Bibliography

A.Armoundas, D, Rosenmaum, Jeremy Ruskin

Electrophysiologic Testing, Electrical Alternans and Signal Averaged Electrocardiology as Predictors of Arrhythmia-free Survival

Mark Estes, Douglas P Zipes, Nabil El Sharif

Value of T Wave Alternans and Signal Averaged ECG as Predictors of Arrhythmia Vulnerability

Mark Estes, Douglas P Zipes, Nabil El Sharif

Electrical Alternans during Rest and Exercise as Predictors of Vulnerability to Ventricular Arrhythmias ( complete paper published on The American Journal of Cardiology 1997;80:1314-1318)

David Rosembaum, Xiaohua Fang, Judith A. Mackall

How to detect ECG T-Wave Alternans in Patients at Risk for Sudden Cardiac Death

Yukihiko Momiyama, W. McKenna, John Camm

Exercise Induced T Wave Alternans as a Marker of High-risk Patients with Hypertrophic Cardiomyopathy

David Leeman, Richard Cohen

Surface laplacian ECG Maps provide a Sensitive and Localizing Measure of Cardiac Ischemia

C. I. Berul, P.J.Wang, Mark Estes

Electrical T-Wave Alternans is Superior to QT of JT Dispersion as Predictive Marker of Ventricular Arrhythmias

Stefan H. Hohnloser, Thomas Klingenheben

T Wave Alternans Measurements: is Exercise Comparable to Pacing (published on Journal of Cardovascular Electrophysiology Vol 8 pp 987-993, September 97)

Markus Zabel, Stefen Hohnloser

Noninvasive Risk Stratification in Patients with Congestive Heart Failure: Comparison of Traditional Risk Markers and T Wave Alternans

J. M. Pastore, S. D. Girouard, D. S. Rosenbaum

Mechanism of Initiation of Ventricular Fibrillation During T Wave Alternans

D. M. Srasser, L. A. Biblo, D. S. Rosenbaum

Is T Wave Alternans Caused by Left Ventricular Hypertrophy ?

Nabil El-Sharif

T W A . A Marker to Vulnerability to Ventricular Tachyarrhithmias

T. Klingenheben, M.Zabel, S. Hohloser

Assessment of T Wave Alternans for Prediction of Recurrent Ventricular Tachycardia/Fibrillation in Patients with an Implantable Defibrillator ( published on Journal of Cardivascular Electrophysiology, Jan 99)

E. Caref, Nabil El-Sherif

Incidence of T Wave Alternans in Normal Subjects, and Effect of Heart Rate on Onset

K. Adachi, T. Shima, Y. Ohnishi

Microvolt Level T Wave Alternans in Patients with Dilated Cardiomyopathy

P.Kluge, A.Posselt, A.Neugebauuer, et.alt

T Wave Alternans in Patients with Idiopatic or Coronary Disease Associated Ventricular Tachycardia

P.Kluge, A. Posselt, T. Walter et alt.

Onset Heart Rate of T Wave Alternans in Different Risk Groups for Ventricular Tachycardia.

Markus Zabel, S. Hohnloser

Microvolt and Macrovolt Alternans of Action Potential and T Wave in Isolated Rabit Heart Model

Masaomi Chinushi, Nabil El-Sherif

QT/T Wave Alternans and arrhythmias in long QT syndrome

Timothy Shinn, Douglas Zipes, William Groth

Amiodarone Reduces T Wave Alternas in Individuals at High Risk for Ventricular Tachyarrhythmias

Michael Coch, Stefen Weber, B Waldecker

Assessment of T Wave Alternans using Atropine

Michael Gold, Dan Bloomfield, Nabil El-Sherif, Mark Estes et al.

T Wave Alternans Predicts Arrhythmia Vulnerability in Patients Undergoing Electrophysiology Study.

Gioia Turitto, Nabil El-Sharif

Comparison of Heart Rate at Onset of T Wave Alternans in Normals and Patients with Malignant Tachyarrhythmias

Thomas Klingenheben, Stephen Hohloser

Predictive Value of T Wave Alternans in Patients with Congestive Heart Failure



Kaufman ES, RosenbaumDS

Microvolt T Wave Alternans is Prevalent in subjects with Congenital Long QT Syndrome

M. Gold, D. Bloomfield, Nabil El-Sharif, M. Estes, W. Groh

A Comparison of T Wave Alternans, Signal Averaged ECG and Electrophysiology Study to Predict Arrhythmia Vulnerability



Joseph Pastore, David Rosenbaum

Mechanism Linking T Wave Alternans to Genesis of Cardiac Fibrillation

( Full text published on Circulation 1999;99:1385-1394)

W. Shimizu, C Antzelevitch

Cellular and Ionic Basis for T Wave Alternans under Long QT Conditions

(Full text published on Circulation 1999;99:1499-1507)

New Abstracts at NASPE 99


D. Bloomfield, Michael Gold, Nabil El-Sherif

A Comparison of TWA and Signal-Averaged ECG in Predicting Outcome of EP Testing

T. Klingenheben, R. Cohen, S. Hohloser

Exercise Induced TWA Identify Patients with Non-Ischemic Dilated Cardiomiopathy at High Risk

K. MacMurdy, M, Gold

TWA Predicts Arrhythmia Vulnerability in Patients with Ischemic Cardiomyopathy

Ronald Pedalino, Gioia Turitto,

TWA is a Strong Predictor of Early Arrhythmia Recurrence in Patients with ICD

B. Ritvo, D Bloomfield

Relationship Between Resting QTc Interval and Development of TWA during Exercise

Gioia Turitto, Irine Kim

Same day Reproducibility of TWA during Bicycle Exercise

Yee Yap, Kudret Aytemir, W. McKenna, Marek Malik, John Camm

Values of TWA, QT Dispersion and Principal Component Analysis Ratio in Patients with Idiopathic Dilated Cardiomiopathy

Yee Yap, Kudret Aytemir, W. McKenna, Marek Malik, John Camm

Microvolt TWA in patients with Arrhythmogenic Ventricular Cardiomyopathy and Dilateted Cardiomyopathy



Kaoru Tanno, Showa University, Tokio Japan

Microvolt T-wave Alternans is related to left ventricular volume overload in  patients with MI

Salim Idriss, Rainbow Babies & Children Hosp.,Case Western Reserve University

Is T-wave Alternans developmentally determined in newborn myocardium?

Joseph Pastore, David Rosenbaum, Case Western Reserve University

T Wave Alternans produces substrate for monomorphyc and polimorphic arrhythmias

Thomas Klingenheben, Stephen Hohnloser, J.W. Goethe University Frankfurt

Indices of Ventricular Repolarization as Predictors of Tachyarrhythmic Events in patients with heart failure and no prior ventricular tachycardia or fibrillation

Pastore, Rosenbaum, Case Western Reserve University

Spatial and temporal heterogeneities of cellular restitution are responsible for arrhythmogenetic discordant Alternans

Daniel Bloomfield, Columbia University, Indianapolis, Elisabeth Kaufman

T Wave Alternans predicts events in patients with syncope undergoing electrophysiology testing

Karen MacMurdy, Michael Gold, University of Maryland

The effect of selective autonomic blockade on T Wave Alternans

MASPE Journal 2000


Daniele Marangoni

T Wave Alternans, a New Arrhythmic Risk Stratification Method: Technical Features and Clinical Experience of a TWA Stress Test System



T. Ikeda

Comparison Between T-Wave Alternans, Late Potentials, QTc Dispersion and Ejection Fraction in Predicting Arrhythmic Events After Acute Myocardial Infarction: A Prospective Study

N. Kuroda

Comparison of Repolarization Abnormality During Exercise in Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy

E. Kaufman

Microvolt Level T-Wave Alternans is Prevalent in a Family With Congenital Long QT Syndrome Due to a HERG Mutation

M. Harada

Relationship Between T Wave Alternans and Cardiac Sympathetic Nervous Dysfunction in Patients With Non-Ischemic Heart Disease

N. Kuroda

Risk Identification by Microvolt-Level T Wave Alternans in Hypertrophic Cardiomyopathy

E. Kaufman

T-Wave Alternans Bursting in Patients at Risk for Sudden Cardiac Death

M. Fedor

T-Wave Alternans During Ventricular Pacing

W. Zareba

Visible T-Wave Alternans in Carriers of LQT1, LQT2, and LQT3 Gene Mutations



Gan-Xin Yan,

Cellular Basis for T-Wave Alternans Associated with Left Ventricular Hypertrophy (LVH),  

Michael Gheung

T-Wave Alternans Threshold During Exercise in Normal Children

Daniel M. Bloomfield

T-Wave Alternans Predicts Events Independent of Ejection Fraction and Etiology of Heart Disease

Yuji Kasamaki

Nicorandil, ATP-Sensitive Potassium Channel Opener, Reduces the Magnitude of T-Wave Alternans

Michael H. Gollob

A Comparison of T-Wave Alternans and Electrophysiologic Testing as a Predictor of Increased Risk for Sudden Death in Hypertrophic Cardiomyopathy

Briike S. Ritvo

Comparison of Exercise and Pharmacological Methods of Measuring T-Wave Alternans,

Karen S. MacMurdy

T-Wave Alternans Predicts Arrhythmia Vulnerability in Patients With Ischemic Cardiomyopathy Undergoing Electrophysiology Study

 Zhilin Qu,

Mechanisms of Discordant Alternans and Induction of Reentrant Arrhythmias: A Simulation

Karen S. MacMurdy

The Influence of Gender on Spontaneous Ventricular Arrhythmias and T-Wave Alternans in Patients with Ischemic Cardiomyopathy

Jan Nemec,

Provocation of Microvoltage T-Wave Alternans by Dobutamine Infusion in Patients With Congenital Long QT Sindrome

Michael  H.


Assessment for Ventricular Arrhythmia Substrate Following Ethanol-Induced Septal Infarction in Hypertrophic Obstructive Cardiomyopathy

Sanjiv M. Narayan

Performance of Repolarization Alternans Determines Arrhythmic Susceptibility in Patients With Left Ventricular Hypertrophy,

Kelley P. Anderson,

Ventricular Repolarization and T-Wave Alternans Preceding the Onset of Spontaneous Sustained Ventricular Tachicardia

ACC 2001


Antony Magnano

Measurement of Microvolt T Wave Alternans During Standard Treadmill Exercise Protocols 

Masanomi Chinushi

Mechanims and Arrhythmogenicity of Discordant QT/T Alternans

Hidetsuna Kitamura

Onset Heart Rate Criteria of Microvolt-Level T-Wave Alternans Provides an Additional Prognostic Value in Nonischemic Dilated Cardiomyopathy

Antony Magnano

Prevalence of T Wave Alternans in Ischemic and Non-ischemic Cardiomiopathy

Yee Guan Yap

T Wave Alternans is Prevalent and Correlates With NYHA Functional Class, LV Function, and Size in Patients With Idiopathic Dilated Cardiomyopathy

Takanori Ikeda

Assessment of Noninvasive Markers in Identifying Patients at Risk in the Brugada Syndrome: Insight Into Risk Stratification

NASPE 2001


Gerian Groenefeld, homas Klingenheben, Yi-Gang Li

Effect of Metoprolol and d,l-Sotalol on Microvolt Level T-Wave Alternans in Patients at Risk for Ventricular Tachyarrhythmias and Sudden Death: Results of a Prospective, Randomized, Double-Blind Study

David J Christini, Cornell Univ. Med. Coll., New York, NY; Kenneth M Stein,

Endocardial Detection of Repolarization Alternans


Blas Echebarria, Alain Karma, Northeastern

Initiation and evolution of discordant alternans under rapid pacing


Kapil Kumar, Harvard Med. Sch., Boston, MA; Khanh P Nguyen,

Intrapericardial Blockade of Transient Outward Current (Ito) Suppresses Ischemia-Induced T-Wave Alternans in Closed-Chest Pigs


 Etienne J Pruvot, CHUV, Lausanne Switzerland

Periods of prolonged transient alternans in APD revealed by delivery of an extrastimulus near  period-doubling bifurcation


Sanjiv M Narayan, Washington U Sch. Med., St. Louis, MO; Bruce Lindsay

Phase Reversal and Magnitude of T-Wave Alternans Predict Spontaneous Ventricular  Arrhythmias and Long-Term Survival

Ahmed F Osman, , MD; Eric J Rashba, Stephen R Shorofsky, Michael R  Gold,

Prognostic value of voltage magnitude during T wave Alternans (TWA) assessment with  exercise and pacing in patients with ischemic cardiomyopathy.

Mariah L Walker, David S Rosenbaum,

Role of Cardiac Memory in Mechanism of T-wave Alternans

 Yuji Konno, Jun Watanabe, Sunao Toda, Jiro Koyama, Aki Yamada

 The relationship between microvolt-level T wave alternans and myocardial inhomogeneity in  cardiac hypertrophy.

ABSTRACT at Europace and ESC 2001


M. Hennersdorf, T. Schmidt, C. Zühlke, C.M. Schannwell, C. Perings, B.E. Strauer


T-Wave-Alternans in patients with arterial hypertension

M. Zabel, C. Breitwieser, D. Sancar, P. Gödde, S. Behrens

T-wave alternans in patients with dual-chamber pacemakers - comparison between atrial, ventricular, and AV sequential pacing

G. Grönefeld, T. Klingenheben, Y.G. Li, S. H. Hohnloser

Pharmacological modification of microvolt-level T-wave alternans by antiadrenergic and repolarization-prolonging drugs: results of a prospective, randomized, double-blind study

J. Nemec1, M.J Ackerman2, D. Tester2, J. Hejlik2, W. Shen2

Relationship between microvoltage T-wave alternans and aperiodic T-wave fluctuations in patients with congenital long QT syndrome

Abstracts at AHA 2001


Takanori Ikeda,  Hirokazu Saito et al.

Assessment of T-Wave Alternans for Prediction of Sudden Cardiac Death After Myocardial Infarction: Results of a Prospective, Japanese Multicenter Study

Thomas Klingenheben, Daniel M Bloomfield,  Stefan H Hohnloser

Microvolt T-Wave Alternans Predicts Ventricular Tachyarrhythmic Events in Non-Ischemic Dilated Cardiomyopathy Patients


Gerian C Groenefeld, Thomas Klingenheben, Yi-Gang Li

Effect of antiadrenergic therapy on the onset heart rate of microvolt level T wave alternans in patients prone to sudden cardiac death

Ahmed F Osman,  Michael R Gold,


Effect of QRS duration on the diagnoastic performance of T wave Alternans

Kenichi Ota, Motoki Hara, Takahiro Koura


Relationship between Action Potential Alternans and Conduction Block in Anisotropic Canine Atrial Tissues




Laura A. Murphy

Female Gender Is Associated With a Decreased Prevalence of T Wave Alternans

Kathryn A Glatter

Exercise-Induced Microvolt T-wave Alternans in the Congenital Long QT Syndrome

Mariko Murata

Effect of B-Blocker Therapy for T-Wave Alternans and Cardiac Sympathetic Function in Patients With Nonischemic Heart Disease

Kaoru Tannao

Different Characteristics of T Wave Alternans Between Polymorphic Ventricular Tachycardia and Monomorphic Ventricular Tachycardia

Norihiro Komiya

Beta-Adrenergic Influences on T Wave Alternans During Pacing in Patients With and Without Ventricular Tachyarrhythmia

Jennifer D. Cohen

Left Bundle Branch Block Reduces the Specificity of T-Wave Alternans Testing

Ramarao S. Lankipalli

Out of Phase T Wave Alternans in Left Ventricular Hypertrophy: Its Role in Ventricular Arrhythmogenesis

*     For any additional information E-mail: dmarangoni@tin.it